Pair Name | Phenethyl isothiocyanate, Cisplatin | ||
Phytochemical Name | Phenethyl isothiocyanate (PubChem CID: 16741 ) | ||
Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
Download
2D
MOL
3D
MOL
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Pair Name | Phenethyl isothiocyanate, Cisplatin | |||
Disease Info | [ICD-11: 2C26.0] | Pleural mesothelioma | Investigative | |
Biological Phenomena | Induction-->ROS generation | |||
In Vitro Model | Meso4 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. |
Meso11 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso13 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso34 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso47 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso56 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso96 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso76 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Meso152 | The mesothelioma cell was established from pleural fluids of patients | Homo sapiens (Human) | N.A. | |
Result | The combination of cisplatin with the natural compound PEITC induces a strong MPM cell death, while remaining safe for PMC, with limited emergence of cell resistance compared to drugs used alone |
No. | Title | Href |
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1 | Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma. Oncotarget. 2014 Nov 30;5(22):11641-52. doi: 10.18632/oncotarget.2604. | Click |