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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Phenethyl isothiocyanate, Cisplatin
Phytochemical Name Phenethyl isothiocyanate (PubChem CID: 16741 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 951
Pair Name Phenethyl isothiocyanate, Cisplatin
Disease Info [ICD-11: 2C26.0] Pleural mesothelioma Investigative
Biological Phenomena Induction-->ROS generation
In Vitro Model Meso4 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso11 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso13 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso34 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso47 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso56 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso96 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso76 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Meso152 The mesothelioma cell was established from pleural fluids of patients Homo sapiens (Human) N.A.
Result The combination of cisplatin with the natural compound PEITC induces a strong MPM cell death, while remaining safe for PMC, with limited emergence of cell resistance compared to drugs used alone
03. Reference
No. Title Href
1 Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma. Oncotarget. 2014 Nov 30;5(22):11641-52. doi: 10.18632/oncotarget.2604. Click
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